Aciclovir desensitisation and rechallenge

Coma secondary to aciclovir neurotoxicity.

Successful desensitisation to Anastrozole.

Dysphonia after Bevacizumab Rechallenge: A Case Report.

Inhibition of vascular endothelial growth factor (VEGF) signaling, an initiator of tumor angiogenesis, inhibits tumor growth and invasion. Bevacizumab, a monoclonal antibody to VEGF, in common use as an adjunct to standard chemotherapy like irinotecan in advanced colorectal cancer, also affects the normal (nontumor) vasculature. Dysphonia or voice changes have been anecdotally reported in patie...

Graded challenge in an aciclovir allergic patient.

An immunocompetent woman presented with a hypersensitivity skin reaction following suppressive therapy with aciclovir for recurrent culture proved genital herpes simplex virus infection. She developed a similar reaction when treatment was changed to famciclovir. Without antiviral suppression her recurrences were frequent and distressing. Graded challenge was performed and she became tolerant to...

Aciclovir, herpes viruses and HIV: a never-ending story.

The present manuscript reviews the study of Delany et al. on the impact of herpes simplex virus type 2 (HSV-2) suppressive aciclovir on genital and plasma HIV-RNA in 269 HSV-2/ HIV-coinfected women in South Africa [1]. HIV infection continues to be among the leading causes of global morbidity and mortality, especially in Africa. An estimated 40 million people are HIV positive with an annual mor...